As a Downstream Process Development Associate, the incumbent will report directly to the Head of Process Development and will be responsible for the day-to-day design and execution of laboratory experiments to develop scalable downstream processes for the purification of recombinant protein or viral vectors.
Responsibilities
Design and execute laboratory experiments to develop a scalable downstream process for the purification of recombinant protein or viral vectors
Knowledge in recombinant protein or viral vector purification processes, including chromatography process (i.e. IEX, affinity, SEC, reversed-phase), ultrafiltration/diafiltration, process scale-up, scale down model qualification, viral and depth filtration
Ability to optimize processes for product purity, recovery, impurity removal, and cost reduction
Assist in tech transfer of the small-scale process to contract manufacturing organization (CMO) for scale-up
Assists with preparing protocols, reports, and test methods
Ability to foster a collaborative work environment with internal and external partners
Skills & Requirements
A good foundation in general scientific practice, principles, and concepts of the discipline.
Basic knowledge of GMP/GLP regulations in cGMP/cGMP manufacturing environment preferred.
Good lab skills.
Good problem-solving and critical thinking skills.
Effective communication skills.
Good MS Excel and Word skills.
Excellent organization skills.
Ability to execute tasks and studies based on the deliverable timeline.
Ability to analyze and summarize routine scientific data.
Ability to function in a rapidly changing environment.
Education & Experience
Ph.D. in Biotechnology, Protein Chemistry, Biochemistry or Chemical/Biochemical Engineering with minimal 2 + years or MS with minimal 6+ years of relevant industrial experience
